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Abstract #5405

Multimodal meta-analysis of neural correlates in first-episode drug-naïve major depressive disorder

Weina Wang1, Youjin Zhao2, Xinyu Hu2, and Qiyong Gong2

1West China Hospital of Sichuan University, Chengdu, People's Republic of China, 2West China Hospital of Sichuan University, People's Republic of China

Evidence of structural and resting-state functional brain abnormalities in MDD has been inconsistent. We conducted the first multimodal meta-analysis of voxel-based morphometry (VBM) and amplitude of low-frequency fluctuation (ALFF) studies in first-episode drug-naïve MDD patients. 15 VBM data setsand 11 ALFF data sets were included. A multimodal meta-analysis was used to highlight brain regions with both structural and functional abnormalities. The multimodal meta-analysis identified conjoint structural and functional differences in the left lateral orbitofrontal cortex and right supplementary motor area. Dissociated anatomical and functional brain abnormalities in MDD were also observed. Meta-analysis revealed in MDD a complex pattern of conjoint and dissociated structural and functional brain abnormalities in brain regions involved in cognition and emotional processing.

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