Abstract #5407

A Comparison of BOLD Signal Amplitude and Electrical Activity During Task Performance in MS and Healthy Control Subjects: Evidence of Neurovascular Decoupling

Mark J Lowe¹, Wanyong Shin¹, Balu Krishnan², and Lael Stone²

¹Imaging Institute, Cleveland Clinic, Cleveland, OH, United States, ²Neurlogic Institute, Cleveland Clinic, Cleveland, OH, United States

Recent reports indicate that cerebrovascular reactivity (CR) may be impaired in multiple sclerosis (MS). Here we report initial studies to use simultaneous measurements of electroencephalography (EEG) and BOLD during performance of a motor task. Using EEG-derived predictors of BOLD response, we show that, while EEG robustly predicts the amplitude of the BOLD signal in healthy control subjects, the estimation is very poor in MS patients. This could be direct evidence of cerebrovascular decoupling of the BOLD signal in MS.

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