This paper presents an original research to investigate the underlying neural mechanism on analgesia at ipsi- or contra-lateral acupuncture with capsaicin-induced allodynia on human body. Our findings further suggested that DMN participants in the modulation of spatial-oriented attention on placebo analgesia as a mechanism underlying the degree to which treatment side corresponding to the pain. Notably, disruptions of the DMN may account for the cognitive and behavioral impairments in chronic pain patients. In addition, it may possibly reflect individual variation in placebo response, thus, as a valuable neural biomarker to predict clinical curative effect in acupuncture treatment.
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