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Abstract #5408

Investigation of neural mechanism underlying ipsi- and contra-lateral acupuncture analgesia in the capsaicin-induced pain model

Xuan Niu1, Yuchen Zhang1, Qiuli Zhang1, Haining Li1, Zhuonan Wang1, Yingxiang Sun1, Lijun Bai2, and Ming Zhang1

1The First Affiliated Hospital of Xi’An Jiaotong University, Xi’an, People's Republic of China, 2The Key Laboratory of Biomedical Information Engineering,Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, People's Republic of China

This paper presents an original research to investigate the underlying neural mechanism on analgesia at ipsi- or contra-lateral acupuncture with capsaicin-induced allodynia on human body. Our findings further suggested that DMN participants in the modulation of spatial-oriented attention on placebo analgesia as a mechanism underlying the degree to which treatment side corresponding to the pain. Notably, disruptions of the DMN may account for the cognitive and behavioral impairments in chronic pain patients. In addition, it may possibly reflect individual variation in placebo response, thus, as a valuable neural biomarker to predict clinical curative effect in acupuncture treatment.

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