Abstract #5409

Altered structure and function reflect chronic pain in patients with idiopathic trigeminal neuralgia

Yuan Wang^1,2, Dongyuan Cao³, Bethany Remeniuk^2,4, David Seminowicz², and Ming Zhang¹

¹Department of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, People's Republic of China, ²Department of Neural and Pain Sciences, School of Dentistry, University of Maryland Baltimore, Baltimore, MD, United States, ³Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, Stomatological Hospital, Xi’an Jiaotong University Health Science Center, Xi'an, People's Republic of China, ⁴Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States

To testify the hypothesis of morphometric and functional alterations of patients with idiopathic trigeminal neuralgia (ITN), we displayed gray matter volume (GMV) reductions in the anterior and middle cingulate cortex (ACC and MCC), insula, and several regions of temporal lobe. Additionally, enhanced functional connectivity was revealed between right insula and ACC, medial prefrontal cortex, posterior cingulate cortex (PCC), and dorsal lateral prefrontal cortex in ITN patients. Furthermore, GMV of left inferior temporal gyrus negatively correlated with pain intensity and disease duration in patients, and connectivity of right insula-ACC was negatively associated with pain scores, depression, and anxiety ratings, respectively.

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