Abstract #5415

Effect of DBS stimulation intervals on brain activity and dopamine release

Christin Y. Sander¹, John Arsenault^1,2, Bruce R Rosen¹, Wim Vanduffel^1,2, and Joseph B Mandeville¹

¹Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States, ²Laboratory of Neuro- and Psychophysiology, Katholieke Universiteit, Leuven, Belgium

In this study, deep brain stimulation with chronically implanted electrodes in the unilateral ventral tegmental area of a monkey was performed. The purpose was to determine stimulation paradigms for a range of inter-stimulation intervals that would enable the simultaneous observation of brain activity using fMRI and endogenous dopamine release using [¹¹C]raclopride-PET. While long inter-stimulation intervals produced a unilateral focal CBV response in the striatum but no change in [¹¹C]raclopride binding, short intervals produced a more widespread CBV response and displacement of [¹¹C]raclopride. This study shows the effect of stimulation parameters on brain activity, neurotransmitter release and its limits of detectability.

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