Abstract #5421

MR Relaxation Properties in MR Coagulation for Vascular Repair

Ming Zhao ^1,2, Ouri Cohen², Erez Nevo³, R.Gilberto Gonzalez², and Jerome L. Ackerman²

¹Department of Physics, University of Massachusetts Lowell, Lowell, MA, United States, ²Martinos Center, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States, ³Robin Medical, Inc., Baltimore, MD, United States

As part of a project to develop MR-induced RF heating of a coagulable biomaterial for minimally invasive repair of vascular lesions, we investigate the relationship between the heat coagulation behavior and MR relaxation properties of egg white. This protein solution is a good model for the analogous behavior of human serum albumin solution, an optimal (but expensive) biomaterial for MR coagulation. We find that large changes in both T₂ and the width of the magnetization transfer spectrum clearly indicate the temperature at which the coagulation process occurs. T₂ and MT weighted MR images identify coagulated material in an aneurysm phantom.

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