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Abstract #5424

A Methodology for Deriving Thermal Dose Model Parameters from Perioperative MR Data

Christopher MacLellan1,2, David Fuentes1,2, Sujit Prabhu3, Ganesh Rao3, Jeffrey S. Weinberg3, John D. Hazle1,2, and R. Jason Stafford1,2

1Imaging Physics, MD Anderson Cancer Center, Houston, TX, United States, 2The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX, United States, 3Neurosurgery, MD Anderson Cancer Center, Houston, TX, United States

Real-time damage estimates provided by Magnetic Resonance Temperature Imaging (MRTI) and appropriate thermal dose models can provide crucial feedback during of thermal ablation procedures. However, these models are not tailored to the post-treatment radiological endpoints that are used to verify the extent of the thermal lesion after therapy. A technique is developed to allow estimation of thermal dose model parameters through retrospective analysis of MRTI and post-treatment imaging. The feasibility of this technique is investigated in a protein coagulation phantom and clinical ablation data.

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