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Abstract #5439

PRF thermometry accuracy at 7.0T for thermal MR applications with and without the presence of fat

Michal Pham1, Yiyi Ji1, Hendrik Paysen1, Eva Oberacker1, Till Huelnhagen1, Thoralf Niendorf1,2,3, and Lukas Winter1

1Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany, 2Experimental and Clinical Research Center (ECRC), a joint cooperation between the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine, Berlin, Germany, 3MRI.TOOLS GmbH, Berlin, Germany

Proton resonance frequency (PRF) shift temperature mapping is influenced by B₀ field drift, temperature dependent electromagnetic property changes that alter phase velocity, alpha calibration and temperature dependent magnetic susceptibility changes. This work details PRF thermometry at 7.0T of a thermal MR setup. In a homogeneous agarose phantom PRF reading accuracy is within the accuracy of fiber optic sensor readings (0.29±0.21)°C. Temperature dependent magnetic susceptibility changes in pure fat lead to significant temperature reading errors. However, for more realistic thermal MR applications in the human brain (ΔT<10°C, volume fat fractions <10-20%), temperature reading accuracy is comparable to water-based samples.

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