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Abstract #5465

Estimating acetate extracellular fraction in the rat brain using diffusion-weighted MRS and modeling of tissue microstructure

Marco Palombo1, Masoumeh Dehghani2, Nicolas Kunz3, Bernard Lanz2, Rolf Gruetter2,3, and Julien Valette1

1Molecular Imaging Research Center (MIRCen), Commissariat à l'Energie Atomique, Fontenay-aux-Roses, France, 2Laboratory of Functional and Metabolic Imaging (LIFMET), Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 3Center for Biomedical Imaging (CIBM), Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

While most brain metabolites detected by in vivo MRS are intracellular, some of them, in particular energy metabolism substrates such as glucose, lactate and acetate, are also known to be significantly present in the extracellular space. Although of high metabolic significance and of practical importance for metabolic flux quantification in labeling studies, the accurate determination of the extracellular fraction remains challenging. Here we propose to use diffusion-weighted MRS combined with modeling of tissue microstructure to estimate acetate’s extracellular fraction in the rat brain, which we find to be ~45%.

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