Abstract #5466

Magnetization exchange between water and downfield metabolites in human brain at 9.4T

Nicole D Fichtner^1,2, Ioannis-Angelos Giapitzakis³, Nikolai Avdievich³, Ralf Mekle⁴, Daniel Zaldivar³, Anke Henning^2,3, and Roland Kreis¹

¹Depts. Radiology and Clinical Research, University Bern, Bern, Switzerland, ²Institute for Biomedical Engineering, UZH and ETH Zurich, Zurich, Switzerland, ³Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, ⁴Center for Stroke Research Berlin (CSB), Charité Universitätsmedizin Berlin, Berlin, Germany

Ultra-high field strengths provide higher signal to noise ratio and improved separation of metabolites in spectroscopy, allowing for more precise characterization of peaks. In particular, this improved peak resolution may be of benefit for characterization of the downfield (5-10ppm) spectrum, which is not yet well characterized; this experiment aims to improve knowledge of downfield peaks by investigating their exchange rates and T₁ values at 9.4T, using inversion transfer experiments and metabolite cycling to allow for non-water suppressed acquisition.

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