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Abstract #5468

Quantitative analysis of in vivo MEGA-PRESS spectra in mice at 9.4T

Jia Guo1, Yanping Sun2, Zhu Gang3, Scott A. Small4, and Douglas L. Rothman5

1Department of Biomedical Engineering, Columbia University, New York, NY, United States, 2Department of Medicine, Columbia University, New York, NY, 3Bruker BioSpin, Billerica, MA, 4Departments of Neurology, Radiology or Psychiatry, Columbia University, New York, NY, 5Departments of Biomedical Engineering or Radiology and Biomedical Imaging, Yale University, New Haven, CT

As of yet J-difference editing methods such as MEGA-PRESS have not been applied to in vivo mouse studies due to low sensitivity and the lack of an automated program to analyze the data. To overcome the obstacles, a fully automated software toolkit MRSMouse was developed for the quantitative analysis of MEGA-PRESS data of the mouse brain. With MRSMouse, we demonstrated the feasibility and reproducibility of MEGA-PRESS for detection of GABA in the mouse brain using a Bruker BioSpec 94/20 9.4T system. During anesthesia, significant decreases of mouse thalamic GABA levels caused by isoflurane were noticed in vivo for the first time.

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