The resonance frequencies of tissue metabolite are affected by cellular-level variations in magnetic susceptibility and the compartmentation of each metabolite. One prominent finding for 1H MRS studies of the brain is differences of the N-Acetylaspartate (NAA) resonance frequency in white matter, which is hypothesized to reflect the inter-axonal localization of this metabolite and susceptibility variations that are dependent on the orientation of the major axonal bundles relative to the applied magnetic field. In this study, the dependence of the NAA frequency on axonal orientation was evaluated using voxel-based analysis of a whole-brain MRSI and diffusion-tensor imaging.
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