Highly efficient sampling strategies based on gradient trajectories can accelerate MRSI studies by 1-2 orders of magnitude compared to conventional acquisitions. However, increasing acceleration and gradient slew rates commonly result in a predictable decline in spectral quality. This report uses rosette trajectory spectroscopic imaging studies to assess how spectral quality and Cramer Rao lower bounds influence how sensitive the MRSI and metabolite ratios are to the expected variation of tissue gray matter.
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