Abstract #5484

A Novel Method for Absolute Metabolite Quantification of 1H Spectroscopic Imaging in the Human Brain Based on Water Measurement with Ultrashort TE

Michal Bittšanský¹, Milada Kováčová², Oliver Štrbák¹, Petra Hnilicová¹, and Dušan Dobrota³

¹Biomedical Center Martin, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia, ²Faculty of Mathematics, Physics and Informatics, Comenius University, Bratislava, Slovakia, ³Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia

We introduce an easily implementable quantification method in vivo based on unsuppressed water measurement (pulse-acquire FID sequence with low flip-angle, short TE and TR and geometry identical to metabolite MRSI). Our quantification is practically independent on water relaxation times, requires only short extra measurement time and is robust enough in pathologies like tumors. We tested its results in a homogeneous phantom, healthy volunteers and tumor patients using a head resonator and an 8-channel array coil for acquisition.

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