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Abstract #5485

Water lineshape fitting method to overcome B0 field inhomogeneity for NMR spectroscopy

Donghyun Hong1, Seyedmorteza Rohani Rankouhi1, Jan-Willem Thielen1, and David G. Norris1,2

1Erwin L. Hahn Institute for Magnetic Resonance Imaging, University of Duisburg-Essen, Essen, Germany, 2Donders Institute for Brain, Cognition and Behavior, Radboud University, Nijmegen, Netherlands

Good B0 field homogeneity is an essential requirement for NMR single voxel spectroscopy. Previously proposed spectral fitting method assumes that all metabolite signals have a Lorentzian shape. However, B0 inhomogeneity may both broaden the linewidth, and modify the lineshape into an asymmetric form. This study has demonstrated a water lineshape fitting method to overcome B0 inhomogeneity using corresponding metabolite fitting models by water lineshape. We obtained similar relative metabolite signal intensities and improved spectral fitting quality regardless of the field homogeneity condition.

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