Abstract #5489

Correlation of Diffusion Weighted Imaging and Echo Planar Correlated Spectroscopic Imaging of Breast Cancer in 3T

Rajakumar Nagarajan^1,2, Maithili Gopalakrishnan², Amir Huda³, Melissa Joines², Nanette Debruhl², and Michael A Thomas²

¹Human Magnetic Resonance Center, Institute for Applied Life Sciences (IALS), University of Massachusetts, Amherst, MA, United States, ²Radiological Sciences, University of Califonia Los Angeles, Los Angeles, CA, United States, ³Physics, California State University, Fresno, CA, United States

In vivo magnetic resonance spectroscopy (MRS) of the breast can be used to measure the level of choline-containing compounds, which is a biomarker of malignancy. The advantage of four dimensional (4D) echo-planar correlated spectroscopic imaging (EP-COSI) enables full slice coverage of the breast facilitating recording of multi-voxel based two-dimensional (2D) MRS than the single-voxel based localized correlated spectroscopy (L-COSY). Also in addition to differentiate malignant from benign, EP-COSI can differentiate the healthy fatty from glandular. Decreased ADC values derived from diffusion weighted imaging (DWI) can be correlated with increased choline and decreased lipids quantified by the EP-COSI technique.

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