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Abstract #5489

Correlation of Diffusion Weighted Imaging and Echo Planar Correlated Spectroscopic Imaging of Breast Cancer in 3T

Rajakumar Nagarajan1,2, Maithili Gopalakrishnan2, Amir Huda3, Melissa Joines2, Nanette Debruhl2, and Michael A Thomas2

1Human Magnetic Resonance Center, Institute for Applied Life Sciences (IALS), University of Massachusetts, Amherst, MA, United States, 2Radiological Sciences, University of Califonia Los Angeles, Los Angeles, CA, United States, 3Physics, California State University, Fresno, CA, United States

In vivo magnetic resonance spectroscopy (MRS) of the breast can be used to measure the level of choline-containing compounds, which is a biomarker of malignancy. The advantage of four dimensional (4D) echo-planar correlated spectroscopic imaging (EP-COSI) enables full slice coverage of the breast facilitating recording of multi-voxel based two-dimensional (2D) MRS than the single-voxel based localized correlated spectroscopy (L-COSY). Also in addition to differentiate malignant from benign, EP-COSI can differentiate the healthy fatty from glandular. Decreased ADC values derived from diffusion weighted imaging (DWI) can be correlated with increased choline and decreased lipids quantified by the EP-COSI technique.

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