Abstract #5492

Simultaneous Hadamard Editing of GABA and glutathione

Muhammad Gulamabbas Saleh^1,2, Georg Oeltzschner^1,2, Kimberly L. Chan^1,2,3, Nicolaas A.J. Puts^1,2, Mark Mikkelsen^1,2, Michael Schär^1,2, Ashley D. Harris^4,5, and Richard A.E. Edden^1,2

¹Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²F. M. Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ³Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁴Department of Radiology, University of Calgary, Calgary, AB, Canada, ⁵Child and Adolescent Imaging Research Program, Alberta Children’s Hospital Research Institute, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada

Hadamard Encoding and Reconstruction of MEGA-Edited Spectroscopy (HERMES) allows the simultaneous, separable editing of GABA and GSH, the two most frequently edited metabolites. Rather than a two-step ON/OFF encoding of MEGA editing, HERMES uses a four-step Hadamard encoding matrix to orthogonally edit multiple metabolites. We demonstrate the method through simulations, phantom and in vivo experiments. HERMES provides excellent separation of GABA and GSH with a two-fold reduction in scan time, while maintaining spectral quality and SNR, compared to sequentially acquired measurements of GABA and GSH using MEGA-PRESS.

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