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Abstract #5492

Simultaneous Hadamard Editing of GABA and glutathione

Muhammad Gulamabbas Saleh1,2, Georg Oeltzschner1,2, Kimberly L. Chan1,2,3, Nicolaas A.J. Puts1,2, Mark Mikkelsen1,2, Michael Schär1,2, Ashley D. Harris4,5, and Richard A.E. Edden1,2

1Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2F. M. Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 3Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 4Department of Radiology, University of Calgary, Calgary, AB, Canada, 5Child and Adolescent Imaging Research Program, Alberta Children’s Hospital Research Institute, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada

Hadamard Encoding and Reconstruction of MEGA-Edited Spectroscopy (HERMES) allows the simultaneous, separable editing of GABA and GSH, the two most frequently edited metabolites. Rather than a two-step ON/OFF encoding of MEGA editing, HERMES uses a four-step Hadamard encoding matrix to orthogonally edit multiple metabolites. We demonstrate the method through simulations, phantom and in vivo experiments. HERMES provides excellent separation of GABA and GSH with a two-fold reduction in scan time, while maintaining spectral quality and SNR, compared to sequentially acquired measurements of GABA and GSH using MEGA-PRESS.

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