Inhibitory neurotransmitter GABA and antioxidant GSH are suggested to be implicated in psychiatric and neurological disorders. These metabolites can be measured in the human brain in vivo using edited 1H-MRS. However, traditional MEGA editing can only be performed for one metabolite at a time, whereas Hadamard encoded spectral editing assesses both metabolites in one sequence, thereby reducing total scan time twofold. As the relatively small GABA and GSH signals as well as the Hadamard paradigm are highly susceptible to frequency drift and motion, real-time frequency and motion correction was added to the sequence.
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