Abstract #5494

The use of MEGA-sLASER with J-refocusing echo time extension to measure the proton T2 of lactate in healthy human brain at 7 T

Chen Chen¹, Bernard Lanz ¹, Carolina Fernandes¹, Susan Francis¹, Penny Gowland¹, and Peter Morris¹

¹Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom

The challenges in T₂ measurement of lactate (Lac) in healthy brain tissue include J-modulation, signal overlaps and low concentration. To overcome these and characterize Lac T₂ relaxation in normal brain tissue at 7T (for the first time), this study used a MEGA-sLASER sequence with J-refocusing echo time extension. The measured T₂ value of Lac was 182±10 ms in healthy human brain (occipital lobe), which can be used for absolute quantification of Lac. The measured T₂ of NAA (169±8 ms) agrees with previous 7T reports. With high sensitivity, this approach showed its potential in detecting changes in Lac T₂ in pathology.

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