Meeting Banner
Abstract #5494

The use of MEGA-sLASER with J-refocusing echo time extension to measure the proton T2 of lactate in healthy human brain at 7 T

Chen Chen1, Bernard Lanz 1, Carolina Fernandes1, Susan Francis1, Penny Gowland1, and Peter Morris1

1Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom

The challenges in T2 measurement of lactate (Lac) in healthy brain tissue include J-modulation, signal overlaps and low concentration. To overcome these and characterize Lac T2 relaxation in normal brain tissue at 7T (for the first time), this study used a MEGA-sLASER sequence with J-refocusing echo time extension. The measured T2 value of Lac was 182±10 ms in healthy human brain (occipital lobe), which can be used for absolute quantification of Lac. The measured T2 of NAA (169±8 ms) agrees with previous 7T reports. With high sensitivity, this approach showed its potential in detecting changes in Lac T2 in pathology.

This abstract and the presentation materials are available to members only; a login is required.

Join Here