GABA editing with frequency-insensitive macromolecule suppression using improved MEGA-SPECIAL sequence (ImSpecial) has been developed. By using a very frequency-selective editing pulse with a pulse width of 30 ms, macromolecule was suppressed without applying a lysine-symmetric editing. An inter and intra-subject repeatability studies were conducted to evaluate GABA editing with MEGA-PRESS and ImSpecial. Compared with GABA+/Cre levels using MEGA-PRESS, GABA/Cre levels using ImSpecial is about 40% less with lower variations for both inter and intra-subject repeatability studies, demonstrating significant MM suppression achieved using ImSpecial.
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