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Abstract #5495

Inter and intra-subject repeatability study of GABA Editing using MEGA-PRESS and ImSpecial Sequence

Meng Gu1, Ralph Hurd2, Laima Baltusis3, and Daniel Spielman1

1Radiology, Stanford University, Stanford, CA, United States, 2GE Healthcare, Menlo Park, CA, United States, 3Center for Cognitive and Neurobiological Imaging, Stanford University, Stanford, CA, United States

GABA editing with frequency-insensitive macromolecule suppression using improved MEGA-SPECIAL sequence (ImSpecial) has been developed. By using a very frequency-selective editing pulse with a pulse width of 30 ms, macromolecule was suppressed without applying a lysine-symmetric editing. An inter and intra-subject repeatability studies were conducted to evaluate GABA editing with MEGA-PRESS and ImSpecial. Compared with GABA+/Cre levels using MEGA-PRESS, GABA/Cre levels using ImSpecial is about 40% less with lower variations for both inter and intra-subject repeatability studies, demonstrating significant MM suppression achieved using ImSpecial.

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