Abstract #5496

Regional GABA concentration comparison in the human brain with the interleaved short TE sLASER and MEGA-sLASER sequence at 7T

Donghyun Hong¹, Seyedmorteza Rohani Rankouhi¹, Jan-Willem Thielen¹, and David G. Norris^1,2

¹Erwin L. Hahn Institute for Magnetic Resonance Imaging, University of Duisburg-Essen, Essen, Germany, ²Donders Institute for Brain, Cognition and Behavior, Radboud University, Nijmegen, Netherlands

GABA is challenging to resolve due to j-couplings and overlapping signals. Previously proposed GABA editing ans short TE approach at UHF make it possible to measure relative GABA concentration. We measured GABA concentration with the interleaved sequence at various brain regions, and found an optimal method to estimate GABA in terms of spectral fitting quality. Occiptal cortex showed a high GABA concentration, and GABA editing approach gave a reliable spectral fitting quality.

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