Abstract #5497

J-difference editing of Creatine in the human brain

Kimberly Chan^1,2,3, Richard Edden^2,3, and Peter Barker^2,3

¹Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD, United States, ²Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins School of Medicine, Baltimore, MD, United States, ³F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

In in vivo proton spectra, Creatine (Cr) and phosphocreatine are usually regarded as non-coupled spin systems (1). This abstract reports on the observation of a small coupling between the creatine CH2 (3.91 ppm) and CH3 (3.02 ppm) groups. A series of J-difference edited experiments were performed both in a phantom and in the human brain to demonstrate that a coupling exists. This coupling was found to have a coupling constant of 0.28 Hz in an isotropic phantom and an even greater coupling in a white matter region.

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