Meeting Banner
Abstract #5499

MEGA-PRESS for simultaneous aspartate and glutamate quantification at 3T.

Petr Menshchikov1,2, Tolibjon Akhadov2, Il'ya Melnikov2, and Natalia Semenova1,2

1Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow, Russian Federation, 2Clinical and Research Institute of Urgent Pediatric Surgery and Trauma, Moscow, Russian Federation

Direct Asp observation using PRESS, STEAM etc. in the human brain is strongly complicated by J-evolution and overlapping with other metabolites. In this work we have adjusted MEGA-PRESS for simultaneous Asp and Glu estimation. According to Vespa simulation as well as phantoms and in vivo studies TE=115ms was chosen as the best for Asp (2.65 and 2.80 ppm) and Glu (2.13 ppm) quantification without overlapping. Asp is the main precursor of neuronal marker NAA. NAA have been shown to be reduced in many disorders. Using this method allows accurate investigation of this important metabolic pathway.

This abstract and the presentation materials are available to members only; a login is required.

Join Here