Abstract #5499

MEGA-PRESS for simultaneous aspartate and glutamate quantification at 3T.

Petr Menshchikov^1,2, Tolibjon Akhadov², Il'ya Melnikov², and Natalia Semenova^1,2

¹Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow, Russian Federation, ²Clinical and Research Institute of Urgent Pediatric Surgery and Trauma, Moscow, Russian Federation

Direct Asp observation using PRESS, STEAM etc. in the human brain is strongly complicated by J-evolution and overlapping with other metabolites. In this work we have adjusted MEGA-PRESS for simultaneous Asp and Glu estimation. According to Vespa simulation as well as phantoms and in vivo studies TE=115ms was chosen as the best for Asp (2.65 and 2.80 ppm) and Glu (2.13 ppm) quantification without overlapping. Asp is the main precursor of neuronal marker NAA. NAA have been shown to be reduced in many disorders. Using this method allows accurate investigation of this important metabolic pathway.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.