Local metabolite concentrations in 60 healthy volunteers were estimated from EPSI data that were analyzed from individual voxel measurements and using spectral integration over a ROI and compared to results from single-voxel acquisitions. Linear regression analysis was used to estimate age-dependence of metabolite concentrations obtained with each of the three different methods. The results were compared with each other for quantitative evaluation of EPSI acquisition at short TE for detection of brain metabolites.
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