Abstract #5503

Integration of Water Referencing with Water Suppression for Absolute Quantification of High-Speed MR Spectroscopic Imaging

Akram Etemadi Amin¹, Elena Ackley², Kevin Fotso², Stephen R Dager³, and Stefan Posse^2,4,5

¹Physisc and Astronomy, U New Mexico, Albuquerque, NM, United States, ²Neurology, U New Mexico, Albuquerque, NM, United States, ³Radiology, U Washington, Seattle, WA, United States, ⁴Physics and Astronomy, U New Mexico, Albuquerque, NM, United States, ⁵Electrical and Computer Engineering, U New Mexico, Albqueruque, NM, United States

We present a new approach with negligible impact on overall scan time that integrates a short water reference acquisition and navigators into the water suppression module, to spatially and spectrally encode the water signal before suppression. We show that this approach enables quantitative 2D and 3D high-speed MR spectroscopic imaging (MRSI) of brain metabolites, for range of pre-localization techniques (slice-selective, slab-selective or PRESS), at short and long TE, and at different slice locations. This method significantly reduces the acquisition time of volumetric MR spectroscopic imaging and is compatible with a wide range of spectroscopic acquisition methods.

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