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Abstract #5511

Robust detection of 2-hydroxyglutarate at 7T high field with a fully adiabatic LASER sequence

Morteza Esmaeili1,2 and Ovidiu Cristian Andronesi1

1Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States, 2Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, NTNU, Trondheim, Norway

With increasing number of high field 7T MR systems in clinical setting, the potential of using advanced MR modalities such as MR spectroscopy is increasing. Imaging 2-hydroxyglutarate (2-HG) can genotype IDH mutations in gliomas. However, the MR signal of this metabolite is overlapped with other resonances, hampering robust quantification of 2-HG. Here we optimized the timing of LASER sequence for robust detection of 2-HG at high field 7T in the presence of B1 inhomogeneity.

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