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Abstract #5512

Effects of Iron Content on J-edited 1H MRS Measures of Cortical Glutathione Investigated In Vivo with Quantitative Susceptibility Mapping (QSM)

Kofi M. Deh 1, Xiangling Mao1, Yize Zhao2, Guoxin Kang1, Pascal Spincemaille1, Yi Wang1, and Dikoma C. Shungu1

1Radiology, Weill Cornell Medicine, New York, NY, United States, 2Healthcare Policy and Research, Weill Cornell Medicine, New York, NY, United States

As the primary intracellular antioxidant, glutathione (GSH) is involved in free radical reactions in vivo involving paramagnetic iron II/III as catalysts or cofactors, suggesting that findings low tissue GSH by MRS could reflect T2 signal loss due to differences in iron content, rather than a genuine antioxidant deficit. This study estimated brain iron content using QSM to assess whether GSH deficits previously reported in patients with chronic fatigue syndrome (CFS) were genuine or simply a T2 signal loss. No iron content differences were found between patients and controls, supporting a genuine GSH deficit in CFS.

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