In this study, the feasibility of acquiring and quantifying short-echo (TE = 14 ms), two-dimensional (2D) STEAM MRSI spectra from the motor cortex was demonstrated by utilizing a non-water-suppressed metabolite-cycling technique. The increase in measurement time by the metabolite-cycling is counterbalanced by a time-efficient concentric ring k-space trajectory. High quality spectra were acquired from 36 localized 2mL voxels in 8 minutes. The metabolite spectra and estimated concentrations were in agreement between non-water-suppressed and water-suppressed MRSI techniques. Findings of this study demonstrate that a non-water-suppressed metabolite-cycling MRSI technique can perform robustly on clinical MRI scanners and within a clinically feasible acquisition time.
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