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Abstract #5522

Metabolite-Cycling Short-Echo Time Magnetic Resonance Spectroscopic Imaging using a Concentric Ring k-space Trajectory

Uzay E Emir1, Brian Burns2, Mark Chiew1, Peter Jezzard1, and Albert Thomas3

1Oxford Centre for Functional MRI of the Brain (FMRIB), University of Oxford, Oxford, United Kingdom, 2Department of Oncology, University of Oxford, Oxford, United Kingdom, 3Department of Radiological Sciences, University of California, Los Angeles, CA, United States

In this study, the feasibility of acquiring and quantifying short-echo (TE = 14 ms), two-dimensional (2D) STEAM MRSI spectra from the motor cortex was demonstrated by utilizing a non-water-suppressed metabolite-cycling technique. The increase in measurement time by the metabolite-cycling is counterbalanced by a time-efficient concentric ring k-space trajectory. High quality spectra were acquired from 36 localized 2mL voxels in 8 minutes. The metabolite spectra and estimated concentrations were in agreement between non-water-suppressed and water-suppressed MRSI techniques. Findings of this study demonstrate that a non-water-suppressed metabolite-cycling MRSI technique can perform robustly on clinical MRI scanners and within a clinically feasible acquisition time.

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