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Abstract #5523

Full-field of view GM and WM spectroscopy in vivo using spatial lipid pattern estimation and BASE-SLIM localization

Peter Adany1, In-Young Choi1,2,3, and Phil Lee1,2

1Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, KS, United States, 2Department of Molecular & Integrative Physiology, University of Kansas Medical Center, 3Department of Neurology, University of Kansas Medical Center

The presence lipids of several orders of magnitude higher concentrations than metabolites in the extracranial tissues present significant challenges for the reliable acquisition and quantification of 1H MRSI, especially in the outer perimeter areas of the brain. We developed a novel spatial lipid reconstruction technique to remove nuisance lipid signals in 1H MRS. We applied lipid reconstruction to MRSI data and performed BASE-SLIM localization on the lipid-subtracted signal. Using this method, high quality compartment spectra of GM and WM could be obtained.

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