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Abstract #5529

Lipid Suppression in 3D Magnetic Resonance Spectroscopic Imaging

Mohammed Goryawala1, Andrew A Maudsley1, and Sulaiman Sheriff1

1University of Miami, Miami, FL, United States

Proton MR spectroscopic imaging (MRSI) is complicated by the presence of subcutaneous lipids, which, if not suppressed before Fourier reconstruction, cause ringing in metabolite maps due to limited k-space sampling. In this study inversion recovery (IR) based lipid suppressed acquisition was compared to non-lipid suppressed acquisition combined with two methods for reducing lipid ringing in whole brain MRS imaging. Results indicate non-lipid suppressed acquisition using the ℓ2-regularization or Papoulis-Gerchberg algorithm for reconstruction is possible without significant ringing artifacts, however, can have a detrimental effect on spectral linewidth and baseline, resulting in smaller spatial coverage than IR based lipid-suppressed acquisition.

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