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Abstract #5530

A Minimum-Phase Shinnar-Le Roux Spectral-Spatial Excitation RF Pulse for Water and Lipid Suppression in 1H MRSI of Body Extremities

Kexin Deng1, Chao Ma2, Kui Ying3, and Georges El Fakhri2

1Biomedical Engineering, Tsinghua University, Beijing, People's Republic of China, 2Gordon Center for Medical Imaging, Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States, 3Engineering Physics, Tsinghua University, Beijing, People's Republic of China

It is challenging to remove nuisance water and lipid signals in 1H-MRSI of body extremities. Strong lipid signals exist both in the subcutaneous layer and bone marrow but also in the muscle, i.e., intramyocellular and extramyocellular lipids. This work presents a novel minimum-phase Shinnar-Le Roux (SLR) spectral-spatial excitation RF pulse for both water and lipid suppression in 1H-MRSI of body extremities. We have validated the proposed method using Bloch equation simulation, phantom, and in vivo studies.

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