Abstract #5530

A Minimum-Phase Shinnar-Le Roux Spectral-Spatial Excitation RF Pulse for Water and Lipid Suppression in 1H MRSI of Body Extremities

Kexin Deng¹, Chao Ma², Kui Ying³, and Georges El Fakhri²

¹Biomedical Engineering, Tsinghua University, Beijing, People's Republic of China, ²Gordon Center for Medical Imaging, Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States, ³Engineering Physics, Tsinghua University, Beijing, People's Republic of China

It is challenging to remove nuisance water and lipid signals in ¹H-MRSI of body extremities. Strong lipid signals exist both in the subcutaneous layer and bone marrow but also in the muscle, i.e., intramyocellular and extramyocellular lipids. This work presents a novel minimum-phase Shinnar-Le Roux (SLR) spectral-spatial excitation RF pulse for both water and lipid suppression in 1H-MRSI of body extremities. We have validated the proposed method using Bloch equation simulation, phantom, and in vivo studies.

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