Abstract #5534

Using 3D MEGA-LASER MRSI to study the role of basal ganglia GABA and Glx in response selection in Manganese neurotoxicology

Ruoyun Ma^1,2, Sandy Snyder^1,3, Ann-Kathrin Stock⁴, Wolfgang Bogner⁵, Ovidiu C. Andronesi⁶, Christian Beste⁴, and Ulrike Dydak^1,2

¹School of Health Sciences, Purdue University, West Lafayette, IN, United States, ²Department of Radiology and Imaging Sciences, Indidana University School of Medicine, Indianapolis, IN, United States, ³Department of Speech, Language, and Hearing Sciences, Purdue University, West Lafayette, IN, United States, ⁴Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine of the Technische Universität Dresden, Germany, ⁵Department of Biomedical Imaging and Image-guided Therapy, High Field MR Center, Medical University of Vienna, Vienna, Austria, ⁶Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States

This pilot study on manganese (Mn) neurotoxicity investigates the association between deficits in response selection and GABA and Glx levels in basal ganglia structures using MEGA-LASER 3D MRSI. Using a novel automated brain-structure-specific quantification approach for GABA+ and Glx, we studied three basal ganglia structures and the thalamus in Mn-exposed welders and controls. A modified Simon task was used to measure selection inhibition. GABA+ and Glx in putamen and globus pallidus were associated with response times in the most complicated experimental scenario in Mn-exposed subjects; whereas thalamic Glx levels were associated with response time for all subjects.

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