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Abstract #5535

Assessment of Neurochemical changes in HIV adults Using Accelerated MR Spectroscopic Imaging and Compressed Sensing Reconstruction

Rajakumar Nagarajan1,2, Eric S Daar3, Ebrahim Haroon4, Zohaib Iqbal2, Neil Wilson2, Sathya Arumugam2, Mario Guerrero3, and Michael A Thomas2

1Human Magnetic Resonance Center, Institute for Applied Life Sciences (IALS), University of Massachusetts, Amherst, MA, United States, 2Radiological Sciences, University of California Los Angeles, Los Angeles, Los Angeles, CA, United States, 3Medicine, Harbor-UCLA Medical Center, Torrance, CA, United States, 4Psychiatry and Behavioral Sciences, Emory School of Medicine, GA, United States

In this work, we have successfully evaluated the accelerated 5D EP-JRESI sequence in 16 adult HIV-infected patients and 15 healthy subjects. Compared to healthy subjects, significant neurochemical changes were observed in HIV+ patients on ART: elevated Ch/Cr ratios in frontal gray, right frontal white and right basal ganglia locations, decreased Glx ratios in the left frontal white, right basal ganglia, occipital gray and white and right insular cortical regions. There was also decreased NAA/Cr in the left basal ganglia and right occipital white regions. In the HIV+ patients, a positive correlation was recorded between the left basal ganglia NAA/Cr and the number of years of ART treatment (r=0.58, p<0.02).

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