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Abstract #5536

Accelerated 3D Echo Planar Spectroscopic Imaging of HIV: Metabolite Changes Correlation with CD4 count and Number of Years of Treatment

Rajakumar Nagarajan1,2, Eric S Daar3, Zohaib Iqbal2, Manoj K Sarma2, Mario Guerrero3, and Michael A Thomas2

1Human Magnetic Resonance Center, Institute for Applied Life Sciences (IALS), University of Massachusetts, Amherst, MA, United States, 2Radiological Sciences, University of California Los Angeles, Los Angeles, Los Angeles, CA, United States, 3Medicine, Harbor-UCLA Medical Center, Torrance, CA, United States

In vivo proton magnetic resonance spectroscopy studies of HIV-infected humans have demonstrated region-specific changes in brain metabolites including N-acetylaspartate, creatine, choline, glutamate/ glutamine, and myo-inositol. Using a 3D EPSI technique, we examined metabolite ratios with respect to creatine in several regions of brain in 18 HIV adults (mean age 46.2 years) and 15 healthy controls (mean age 43.4 years). We have demonstrated for the first time the feasibility of a novel accelerated 3D EPSI method in HIV-infected adults compared to age matched healthy controls and correlated with CD4 counts and number of years of treatment.

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