Meeting Banner
Abstract #5562

Gadolinium Containing Metabolites in Brain Tissue. A Study in Rats

Thomas Frenzel1, Gregor Jost1, Chirag Apte2, and Hubertus Pietsch1

1Bayer AG, Berlin, Germany, 2University of British Columbia, Vancouver, BC, Canada

After the repeated dosing of linear or macrocyclic GBCAs in rats, the brain was fractionated 3 and 24d p.i. Cerebrum, cerebellum and pons were separated, homogenized and divided into an insoluble and soluble fraction, which was separated into low and high molecular weight molecules. The gadolinium concentration in the brain was very low. A large portion of the Gd in the linear GBCA groups was found in the insoluble fraction and a smaller portion in large macromolecules. The Gd in the macrocyclic GBCA groups was only found in the soluble fraction and in small molecules. Gd excretion was still ongoing.

This abstract and the presentation materials are available to members only; a login is required.

Join Here