Abstract #5563

In vivo measurements of gadolinium accumulation in bone of healthy individuals following administration of gadolinium-based contrast agents: a pilot study

Michelle L. Lord¹, Fiona E. McNeill², James L. Gräfe³, Michael D. Noseworthy^4,5, and David R. Chettle²

¹Radiation Sciences Graduate Program, McMaster University, Hamilton, ON, Canada, ²Department of Physics and Astronomy, McMaster University, Hamilton, ON, Canada, ³Department of Physics, Ryerson University, Toronto, ON, Canada, ⁴McMaster School of Biomedical Engineering, McMaster University, Hamilton, ON, Canada, ⁵Department of Electrical and Computer Engineering, McMaster University, Hamilton, ON, Canada

The use of gadolinium (Gd) based contrast agents is being questioned due to its recently discovered retention in healthy individuals following administration. Our newest generation x-ray fluorescence system has been used in a small pilot study for in vivo Gd measurements in bones of healthy individuals, who have previously received these contrast agents. Preliminary results show a significant difference between the Gd-exposed and control groups, suggesting Gd accumulation in healthy individuals. Our system has performed the first human in vivo measurement of Gd in bone and has the potential to be used in further studies of accumulation in the body.

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