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Abstract #5564

Characterization of Gadolinium Deposition in the Brain Manifest as T2-hypointensity and T1-hyperintensity Associated with Repeat Monthly Triple-Dose Gadopentetate Dimeglumine Administration for 2 years in the BECOME Trial

Paul Allen DiCamillo1,2, Michael Benjamin Shvarts1,2, Ravi Bhasker Patel2,3,4, Jhimli Mitra3, Pallavi Tiwari3, Stuart D Cook5, Diego Cadavid5, Robert T Naismith6, Samantha Lancia6, and Leo J Wolansky1,2

1Radiology, University Hospitals Cleveland Medical Center, Cleveland, OH, United States, 2Case Western Reserve University School of Medicine, Cleveland, OH, United States, 3Department of Biomedical Engineering, Case Western Reserve University School of Medicine, Cleveland, OH, United States, 4Radiation Oncology, University Hospitals Cleveland Medical Center, Cleveland, OH, United States, 5Department of Neurology, Rutgers-New Jersey Medical School, Newark, NJ, United States, 6Neurology, Washington University School of Medicine, St. Louis, MO, United States

We characterize the brain parenchymal deposition of Gadolinium (Gd) in the dentate nucleus (DN) and globus pallidus (GP) in a cohort of 16 subjects with multiple sclerosis (MS), each of whom had systematically received one year of serial monthly triple dose Gd (3-dose Gd) and optional additional monthly exposure for a second year. Progressive increase in T1 signal and decrease in T2 signal is found in both the dentate nucleus and globus pallidus.

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