Abstract #5564

Characterization of Gadolinium Deposition in the Brain Manifest as T2-hypointensity and T1-hyperintensity Associated with Repeat Monthly Triple-Dose Gadopentetate Dimeglumine Administration for 2 years in the BECOME Trial

Paul Allen DiCamillo^1,2, Michael Benjamin Shvarts^1,2, Ravi Bhasker Patel^2,3,4, Jhimli Mitra³, Pallavi Tiwari³, Stuart D Cook⁵, Diego Cadavid⁵, Robert T Naismith⁶, Samantha Lancia⁶, and Leo J Wolansky^1,2

¹Radiology, University Hospitals Cleveland Medical Center, Cleveland, OH, United States, ²Case Western Reserve University School of Medicine, Cleveland, OH, United States, ³Department of Biomedical Engineering, Case Western Reserve University School of Medicine, Cleveland, OH, United States, ⁴Radiation Oncology, University Hospitals Cleveland Medical Center, Cleveland, OH, United States, ⁵Department of Neurology, Rutgers-New Jersey Medical School, Newark, NJ, United States, ⁶Neurology, Washington University School of Medicine, St. Louis, MO, United States

We characterize the brain parenchymal deposition of Gadolinium (Gd) in the dentate nucleus (DN) and globus pallidus (GP) in a cohort of 16 subjects with multiple sclerosis (MS), each of whom had systematically received one year of serial monthly triple dose Gd (3-dose Gd) and optional additional monthly exposure for a second year. Progressive increase in T1 signal and decrease in T2 signal is found in both the dentate nucleus and globus pallidus.

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