We evaluated the efficacy of a new manganese-based contrast agent, Mn-PyC3A, in contrast-enhanced MR angiography by comparison to Gd-DTPA in a baboon model at 3T. Mn-PyC3A clearance was assessed by dynamically scanning the excretory organs and performing serial blood draws out to 60 min. Mn-PyC3A plasma clearance and metabolism were quantified from the drawn blood. Mn-PyC3A generates equivalent vessel-to-muscle contrast-to-noise ratios as Gd-DTPA at 3T, clears via a mixed renal and hepatobiliary pathway, and is excreted unchanged. Mn-PyC3A is a functionally equivalent gadolinium-free alternative for contrast-enhanced MRI angiography.
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