The infiltration of six marketed and one experimental gadolinium based contrast agents (GBCA) from blood into the cerebrospinal fluid (CSF) was evaluated in rats by repeated fluid attenuated (FLAIR) MRI up to 4h. Quantitative gadolinium measurements in CSF samples (4.5 and 24h) were performed by ICP-MS. No differences in penetration and distribution into the CSF were observed for the marketed GBCAs. FLAIR imaging demonstrates a kinetic from the inner CSF cavities to the subarachnoid space, suggesting an infiltration via the choroid plexus and a passive distribution with CSF flow. After 24h an almost complete GBCA clearance from CSF was observed.
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