Abstract #5595

Unique molecular signatures to distinguish immunotherapy responding and resistant cell lines in melanoma by NMR spectroscopy and MR hyperpolarization

Shivanand Pudakalakatti¹, Ashvin Jaiswal², Prasanta Dutta¹, Michael Curran², and Pratip Bhattacharya¹

¹Department of cancer systems imaging, University of Texas M D Anderson Cancer Center, Houston, TX, United States, ²Department of Immunology, University of Texas M D Anderson Cancer Center, Houston, TX, United States

The cancer immunotherapy has brought new ray of hope in cancer patients with its capability of curing cancer with less side effects. However not all patients responds to therapy. In this study we have employed Nuclear Magnetic Spectroscopy (NMR) and in vivo hyperpolarized 1-13C pyruvate magnetic resonance spectroscopy (MRS) to differentiate immunotherapy responding from immunotherapy resisting melanoma.

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