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Abstract #5598

High-resolution MRS characterization of malignant ascites in two different models of ovarian cancer

Santosh K Bharti1, Flonné Wildes1, Chien-Fu Hung2, TC Wu2, Zaver M Bhujwalla1,3, and Marie-France Penet1,3

1JHU ICMIC Program, Division of Cancer Imaging Research, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2Pathology, The Johns Hopkins University School of Medicine, 3Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine

Malignant ascites occurs in approximately 37% of terminal ovarian cancer patients. It significantly contributes to poor quality of life and mortality. Advances in understanding malignant ascites formation and finding new therapeutic options are urgently needed. High-resolution proton magnetic resonance spectroscopy provides opportunities to characterize biofluid metabolites and can be easily translated to the clinic. Here, we are investigating the metabolic profile of ascites obtained in two different experimental models of ovarian cancer. To further understand the differences observed between both models, we completed our study by analyzing the metabolic profiles of those cells in culture and their corresponding conditioned media.

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