Abstract #5599

High-resolution 1H MRS human plasma profiling of pancreatic ductal adenocarcinoma

Santosh K Bharti¹, Michael Goggins^2,3, and Zaver M Bhujwalla^1,3

¹JHU ICMIC Program, Division of Cancer Imaging Research, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²Departments of Pathology and Medicine, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, United States

The dismally poor 5 year survival rate of less than 6% in pancreatic ductal adenocarcinoma (PDAC) increases to ~50% with early stage PDAC making early detection critically important. Metabolic characterization of patient plasma samples provides a unique opportunity to identify biomarkers to assist in routine screening to detect of PDAC. Here, in a preliminary study, we have characterized the metabolic profiles of plasma samples from normal, benign, and PDAC patients. Even with a limited sample we identified a significant increase in β-hydroxybutyrate, acetate, acetoacetate, lactate and pyruvate in PDAC compared to normal plasma.

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