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Abstract #5600

Interrogating Liver Metabolic Stress due to Cancer-Induced Cachexia

Santosh K Bharti1, Paul T Winnard Jr.1, Yelena Mironchik1, Anirban Maitra2, and Zaver M Bhujwalla1,3

1JHU ICMIC Program, Division of Cancer Imaging Research, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2MD Anderson Cancer Center, The University of Texas, Houston, TX, United States, 3Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, United States

Cachexia is a poorly understood metabolic syndrome characterized by cancer-induced tissue wasting and weight loss. Cachexia occurs with the highest frequency and severity in pancreatic ductal adenocarcinoma (PDAC). To further understand this syndrome, here we used 1H MRS to analyze liver metabolites in mice with and without cachexia-inducing PDAC. We detected profound liver weight loss in cachectic mice. 1H MR spectra identified significant depletion of lactate, glucose and glutathione in cachectic mice that provide new insights into the syndrome and may present novel strategies to prevent or reduce cachexia-induced weight loss and the morbidity and mortality associated with the syndrome.

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