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Abstract #5606

Metabolomic Analysis of Dendritic Cell Vaccination

Ram Bahadur Khattri1, Farhad Dastmalchi2, James R. Rocca3, Maryam Rahman2, and Matthew Merritt4

1Department of Biochemistry & Molecular Biology, University of Florida, Gainesville, FL, United States, 2Department of Neurosurgery, University of Florida, Gainesville, FL, United States, 3Mcknight Brain Institute, University of Florida, Gainesville, FL, United States, 4Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL, United States

We use 1H NMR metabolomics to measure the impact of immunotherapy intended to target glioblastoma multiforme in a murine model. Cellular immunotherapy is a promising new platform for cancer treatment. Analysis of the urine of C57Bl6 mice revealed a set of metabolites associated with changes in glycolysis after immunotherapy treatment.

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