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Abstract #5607

NMR Based Metabolomics of Human Filtered-Serum: An Appraisal of Chronic Stable Angina and Myocardial Infarction

Ashish Gupta1, Sudeep Kumar2, Shiridhar kashyap2, Deepak Kumar3, and Aditya Kapoor2

1metabolomics, Centre of Biomedical Research, Lucknow, India, 2Cardiology, SGPGIMS, Lucknow, India, 3Metabolomics, Centre of Biomedical Research, Lucknow, India

To address the shortcomings of the conventional biochemical approach for the precise identification of myocardial infarction (MI), and differentiation from chronic stable angina (CSA), and normal coronary (NC) subjects, we applied filtered serum based metabolomics using 1H NMR spectroscopy. The study comprises filtered sera from CAD [CSA (n=88, MI (n=90)], and NC (n=55) subjects. NMR-measured metabolites and clinical evaluation data were examined separately using chemometric approach to probe the signature descriptors for each cohort. This approach reveals that filtered serum based metabolic profiling can differentiate not only NC from CSA and MI but also CSA from MI.

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