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Abstract #5621

Feasibility of localized, 1H decoupled natural abundance 13C-MRS of human brain at 7T using double tuned array coils and polarization transfer

Guillaume Donati1 and Rolf Gruetter1,2

1Laboratory for Functional and Metabolic Imaging, CIBM, EPFL, Lausanne, Switzerland, 2Department of Radiology, Universities of Lausanne and Geneva, Lausanne, Geneva, Switzerland

The inherent low sensitivity of 13C-MRS makes detection of natural abundance metabolites in human brain challenging. We aimed to demonstrate that double-tuned array coils are particularly well-suited for 13C-MRS studies in vivo, as they provide high sensitivity and high transmit efficiency over a large FOV. To further enhance the SNR, DEPT sequence was used to transfer polarization from 1H to 13C, as well as WALTZ-16 1H-decoupling, all within FDA guidelines. Natural abundance metabolites such as glutamate, glutamine, NAA and creatine were successfully detected and decoupled in 30 minutes acquisition time, showing strong efficiency and sensitivity of our measurement setup.

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