Meeting Banner
Abstract #5623

Simultaneous measurement of metabolic rates of oxygen via 17O NMR imaging in brain and muscle tissue of rat at 16.4T

Hannes Michel Wiesner1,2, Dávid Zsolt Balla3, Klaus Scheffler2,4, Kamil Ugurbil1, Xiao-Hong Zhu1, Wei Chen1, Kamil Uludag5, and Rolf Pohmann2

1CMRR, Radiology, University of Minnesota Medical School, Minneapolis, MN, United States, 2MRC Department, MPI for Biological Cybernetics, Tübingen, Germany, 3Department of Physiology of Cognitive Processes, MPI for Biological Cybernetics, Tübingen, Germany, 4Radiology, University of Tübingen, Tübingen, Germany, 5MBIC, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, Netherlands

In this study, we exploit the feasibility of the 17O MRSI technique for simultaneous measurement of the metabolic rates of oxygen in brain and surrounding muscle based on ROI analysis of dynamics of tissue H217O time courses acquired at 16.4T with 3D 17O MRSI. An established three-phase model originally developed for brain application was extended with certain assumptions applied to the resting temporalis muscle of rats.

This abstract and the presentation materials are available to members only; a login is required.

Join Here