Abstract #5623

Simultaneous measurement of metabolic rates of oxygen via 17O NMR imaging in brain and muscle tissue of rat at 16.4T

Hannes Michel Wiesner^1,2, Dávid Zsolt Balla³, Klaus Scheffler^2,4, Kamil Ugurbil¹, Xiao-Hong Zhu¹, Wei Chen¹, Kamil Uludag⁵, and Rolf Pohmann²

¹CMRR, Radiology, University of Minnesota Medical School, Minneapolis, MN, United States, ²MRC Department, MPI for Biological Cybernetics, Tübingen, Germany, ³Department of Physiology of Cognitive Processes, MPI for Biological Cybernetics, Tübingen, Germany, ⁴Radiology, University of Tübingen, Tübingen, Germany, ⁵MBIC, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, Netherlands

In this study, we exploit the feasibility of the ¹⁷O MRSI technique for simultaneous measurement of the metabolic rates of oxygen in brain and surrounding muscle based on ROI analysis of dynamics of tissue H₂¹⁷O time courses acquired at 16.4T with 3D ¹⁷O MRSI. An established three-phase model originally developed for brain application was extended with certain assumptions applied to the resting temporalis muscle of rats.

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