Abstract #5625

Study of MR characteristics of anti-psychotic drugs using fluorine (19F) MR spectroscopy at 9.4 T

Chu-Yu Lee¹, In-Young Choi^1,2,3, Jean C Dinh⁴, William M Brooks^1,2, J. Steven Leeder^4,5, and Phil Lee^1,3

¹Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, KS, United States, ²Department of Neurology, University of Kansas Medical Center, Kansas City, KS, United States, ³Department of Molecular & Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, United States, ⁴Division of Clinical Pharmacology, Toxicology, and Therapeutic Innovation, Children's Mercy Hospital, Kansas City, MO, United States, ⁵Department of Pediatrics, Children's Mercy Hospital, Kansas City, MO, United States

19F MRS allows assessment of fluorine containing anti-psychotic drugs in the brain. However, the reliable quantification remains challenging due to low drug concentrations and MR characteristics of the drugs are not well understood. This study aimed to characterize MR properties of four anti-psychotic drugs: pimozide, paliperidone, risperidone, and racemic fluoxetine, in phantoms at 9.4 T. Our results demonstrated that pimozide, paliperidone and risperidone showed over 50 ppm differences in chemical shifts and over 200 ms differences in T1 and T2 relaxation times compared with racemic fluoxetine. These different MR characteristics may have important implications for the 19F MRS technique development.

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