Abstract #5633

Interregional associations between GABA+, Glx and BOLD contrast changes during acute pain perception in the human brain – A combined 1H fMRS and fMRI study

Marianne Cleve¹, Alexander Gussew¹, Gerd Wagner², and Jürgen R. Reichenbach¹

¹Medical Physics Group, Institute of Diagnostic and Interventional Radiology, Jena University Hospital - Friedrich Schiller University Jena, Jena, Germany, ²Psychiatric Brain & Body Research Group Jena, Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany

Possible associations between BOLD and left insular GABA+/tCr and Glx/tCr levels were investigated by conducting whole brain fMRI measurements and ¹H MEGA-PRESS MRS at 3 T in healthy subjects prior to and during acute pain stimulation. A significant negative correlation between insular resting state GABA+/tCr levels and BOLD response was obtained in the supplementary motor area with transition to the mid-cingulate cortex. Furthermore, insular ΔGlx revealed a significant positive association with BOLD signal in the left anterior and right posterior insula. These findings suggest interregional interrelations between metabolite levels and stimulus induced BOLD response in the pain processing network.

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