Abstract #5633

Interregional associations between GABA+, Glx and BOLD contrast changes during acute pain perception in the human brain – A combined 1H fMRS and fMRI study

Marianne Cleve¹, Alexander Gussew¹, Gerd Wagner², and Jürgen R. Reichenbach¹

¹Medical Physics Group, Institute of Diagnostic and Interventional Radiology, Jena University Hospital - Friedrich Schiller University Jena, Jena, Germany, ²Psychiatric Brain & Body Research Group Jena, Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany

Possible associations between BOLD and left insular GABA+/tCr and Glx/tCr levels were investigated by conducting whole brain fMRI measurements and ¹H MEGA-PRESS MRS at 3 T in healthy subjects prior to and during acute pain stimulation. A significant negative correlation between insular resting state GABA+/tCr levels and BOLD response was obtained in the supplementary motor area with transition to the mid-cingulate cortex. Furthermore, insular ΔGlx revealed a significant positive association with BOLD signal in the left anterior and right posterior insula. These findings suggest interregional interrelations between metabolite levels and stimulus induced BOLD response in the pain processing network.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.