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Abstract #5634

Abnormal developmental trajectories of brain metabolites contributed to abnormal muscle tone development in infants with prenatal methamphetamine and tobacco-exposure

Linda Chang1, Sara Hayama1, Steven Buchthal1, Chathura Siriwardhana1, Daniel Alicata1, Zachary Pang1, Tricia Wright1, Jon Skranes2, and Thomas Ernst1

1University of Hawaii at Manoa, Honolulu, HI, United States, 2Pediatrics, Sorlandet Hospital, Arendal, Norway

In prior studies, children with prenatal methamphetamine-(PME) or tobacco-exposure (PTE) showed elevated brain metabolites levels. The current study evaluated infants with PME and PTE during the first 5 months of life and found abnormal developmental trajectories of metabolites in the frontal white matter, with abnormally lower levels of total creatine [tCr], N-acetylaspartate [NAA], and glumate+glutamine [Glx] at baseline, and steeper developmental trajectories that resulted in normal or elevated levels after 2-months old. Furthermore, the trajectories of basal ganglia-[NAA] and corticospinal tract-[tCr] further contributed to the slower muscle tone development in PME infants, especially the males.

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